n-3 Fatty acid derived endocannabinoids: a new link between fish oil and inflammation

Wageningen University2012 Thesis by Mr. Michiel G.J. Balers expands on Omega 3’s fatty acid derived endocannabinoids as a new link between fish oil and inflammation.

It is well established that dietary n-3 fatty acid intake is associated with anti-inflammatory effects. The mechanisms behind these effects have been shown to include binding to nuclear and G-protein coupled receptors, interactions with eicosanoid synthesis, and conversion to resolvins which display anti-inflammatory properties. Fatty acids are also precursors for N-acylethanolamines (NAEs)/endocannabinoids, but the anti-inflammatory effects of n-3 fatty acids have not been linked to the endocannabinoid system before. This 2012 thesis describes the link between (dietary) fatty acids, NAEs/endocannabinoids, and inflammation.

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